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The results were found to be essentially similar. Discussion In a large multiethnic, nationally representative sample, we found that increasing serum BPA levels were strongly associated with PAD. The observed association was independent of the confounding factors of smoking, BMI, alcohol intake, diabetes mellitus, hypertension, and serum cholesterol level. Our study adds to the emerging evidence suggesting a role for environmental exposure to BPA in cardiovascular disease in humans Lang et al. BPA is an environmental chemical used as a constituent monomer in polycarbonate plastics, which are used extensively in drink containers and food packaging and in the production of oxidants used in the lining of canned goods Vandenberg et al. Exposure to BPA is believed to be mainly through dietary intake with additional exposure through water, dental sealants, inhalation of household dusts, and exposure through skin Vandenberg et al. Several lines of recent evidence suggest that an association between urinary BPA levels and PAD may be biologically plausible. Animal studies have suggested that BPA exposure may have a role in CVD development through several mechanisms, including the role of BPA in weight gain and obesity development potentially through its action on preadipocytes Masuno et al. Alonso-Magdalena et al. Furthermore, in animal models BPA has been shown to induce endothelial cell injury mediated through oxidative stress Hennig et al.

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